PittsburghV1, Main, Exploration, bibRecord, 002382

Longitudinal Assessment of the Menopausal Transition, Endogenous Sex Hormones, and Perception of Physical Functioning: The Study of Women’s Health Across the Nation

Identifieur interne : 002382 ( Main/Exploration ); précédent : 002381; suivant : 002383

Longitudinal Assessment of the Menopausal Transition, Endogenous Sex Hormones, and Perception of Physical Functioning: The Study of Women’s Health Across the Nation

Auteurs : Samar R. El Khoudary ; Candace K. Mcclure ; Trang Vopham ; Carrie A. Karvonen-Gutierrez ; Barbara Sternfeld ; Jane A. Cauley ; Naila Khalil ; Kim Sutton-Tyrrell

Source :

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences [ 1079-5006 ] ; 2014.

RBID : PMC:4158400

Descripteurs français

KwdFr :
- Activité motrice, Activités de la vie quotidienne, Adulte, Adulte d'âge moyen, Autorapport, Femelle, Hormones sexuelles stéroïdiennes (physiologie), Humains, Indicateurs d'état de santé, Ménopause (physiologie), Santé des femmes, État de santé, Études de cohortes.
MESH :
- physiologie : Hormones sexuelles stéroïdiennes, Ménopause.
- Activité motrice, Activités de la vie quotidienne, Adulte, Adulte d'âge moyen, Autorapport, Femelle, Humains, Indicateurs d'état de santé, Santé des femmes, État de santé, Études de cohortes.

English descriptors

KwdEn :
- Activities of Daily Living, Adult, Cohort Studies, Female, Gonadal Steroid Hormones (physiology), Health Status, Health Status Indicators, Humans, Menopause (physiology), Middle Aged, Motor Activity, Self Report, Women's Health.
MESH :
- chemical , physiology : Gonadal Steroid Hormones.
- physiology : Menopause.
- Activities of Daily Living, Adult, Cohort Studies, Female, Health Status, Health Status Indicators, Humans, Middle Aged, Motor Activity, Self Report, Women's Health.

Abstract

Background.

To evaluate the longitudinal associations between menopausal status, related hormonal changes, and level of self-reported physical functioning.

Methods.

Study included 2,495 women (age: 45–57 between 2000 and 2001) from the Study of Women’s Health Across the Nation. Physical functioning scale of the Medical Outcomes Study Short-Form (SF-36; score 0–100) was categorized as: no limitation (86–100), moderate limitation (51–85), and substantial limitation (0–50). Study variables were collected between 2000 (visit-04) and 2011 (visit-12) at five timepoints. Statistical models were adjusted for age at visit-04, time since visit-04, ethnicity, site, economic status, level and change in body mass index, level and change in physical activity, and presence of comorbid conditions.

Results.

In final models, natural and surgical postmenopausal women had significantly higher odds of functional limitation, compared with premenopausal women. Less reduction in estradiol and testosterone since visit-04 were significantly associated with lower odds of functional limitation, while greater increase in sex hormone-binding globulin was associated with higher odds of functional limitation.

Conclusions.

Our findings suggest the menopause-related changes in endogenous sex hormones as a possible mechanism of action to explain the greater limitation in physical functioning reported in women at midlife.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158400

DOI: 10.1093/gerona/glt285
PubMed: 24465026
PubMed Central: 4158400

Affiliations:

Le document en format XML

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<term>Adult</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Gonadal Steroid Hormones (physiology)</term>
<term>Health Status</term>
<term>Health Status Indicators</term>
<term>Humans</term>
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<term>Activités de la vie quotidienne</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Autorapport</term>
<term>Femelle</term>
<term>Hormones sexuelles stéroïdiennes (physiologie)</term>
<term>Humains</term>
<term>Indicateurs d'état de santé</term>
<term>Ménopause (physiologie)</term>
<term>Santé des femmes</term>
<term>État de santé</term>
<term>Études de cohortes</term>
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<term>Ménopause</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Menopause</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term>
<term>Adult</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Health Status</term>
<term>Health Status Indicators</term>
<term>Humans</term>
<term>Middle Aged</term>
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<term>Self Report</term>
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<term>Activités de la vie quotidienne</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Autorapport</term>
<term>Femelle</term>
<term>Humains</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Background.</title>
<p>To evaluate the longitudinal associations between menopausal status, related hormonal changes, and level of self-reported physical functioning.</p>
</sec>
<sec><title>Methods.</title>
<p>Study included 2,495 women (age: 45–57 between 2000 and 2001) from the Study of Women’s Health Across the Nation. Physical functioning scale of the Medical Outcomes Study Short-Form (SF-36; score 0–100) was categorized as: no limitation (86–100), moderate limitation (51–85), and substantial limitation (0–50). Study variables were collected between 2000 (visit-04) and 2011 (visit-12) at five timepoints. Statistical models were adjusted for age at visit-04, time since visit-04, ethnicity, site, economic status, level and change in body mass index, level and change in physical activity, and presence of comorbid conditions.</p>
</sec>
<sec><title>Results.</title>
<p>In final models, natural and surgical postmenopausal women had significantly higher odds of functional limitation, compared with premenopausal women. Less reduction in estradiol and testosterone since visit-04 were significantly associated with lower odds of functional limitation, while greater increase in sex hormone-binding globulin was associated with higher odds of functional limitation.</p>
</sec>
<sec><title>Conclusions.</title>
<p>Our findings suggest the menopause-related changes in endogenous sex hormones as a possible mechanism of action to explain the greater limitation in physical functioning reported in women at midlife.</p>
</sec>
</div>
</front>
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<affiliations><list></list>
<tree><noCountry><name sortKey="Cauley, Jane A" sort="Cauley, Jane A" uniqKey="Cauley J" first="Jane A." last="Cauley">Jane A. Cauley</name>
<name sortKey="El Khoudary, Samar R" sort="El Khoudary, Samar R" uniqKey="El Khoudary S" first="Samar R." last="El Khoudary">Samar R. El Khoudary</name>
<name sortKey="Karvonen Gutierrez, Carrie A" sort="Karvonen Gutierrez, Carrie A" uniqKey="Karvonen Gutierrez C" first="Carrie A." last="Karvonen-Gutierrez">Carrie A. Karvonen-Gutierrez</name>
<name sortKey="Khalil, Naila" sort="Khalil, Naila" uniqKey="Khalil N" first="Naila" last="Khalil">Naila Khalil</name>
<name sortKey="Mcclure, Candace K" sort="Mcclure, Candace K" uniqKey="Mcclure C" first="Candace K." last="Mcclure">Candace K. Mcclure</name>
<name sortKey="Sternfeld, Barbara" sort="Sternfeld, Barbara" uniqKey="Sternfeld B" first="Barbara" last="Sternfeld">Barbara Sternfeld</name>
<name sortKey="Sutton Tyrrell, Kim" sort="Sutton Tyrrell, Kim" uniqKey="Sutton Tyrrell K" first="Kim" last="Sutton-Tyrrell">Kim Sutton-Tyrrell</name>
<name sortKey="Vopham, Trang" sort="Vopham, Trang" uniqKey="Vopham T" first="Trang" last="Vopham">Trang Vopham</name>
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Longitudinal Assessment of the Menopausal Transition, Endogenous Sex Hormones, and Perception of Physical Functioning: The Study of Women’s Health Across the Nation

Longitudinal Assessment of the Menopausal Transition, Endogenous Sex Hormones, and Perception of Physical Functioning: The Study of Women’s Health Across the Nation

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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